Pharmacology Paper-2 (Supplementary), 2021 MBBS Batch ABVMU Lucknow

ATAL BIHARI VAJPAYEE MEDICAL UNIVERSITY, LUCKNOW

MBBS DEGREE - IInd PROFESSIONAL SUPPLEMENTARY EXAMINATION - JUNE 2024

PHARMACOLOGY - PAPER - II

PAPER CODE: 2421230005 SECTION A - Multiple Choice Questions (MCQs) SET: B

Note: Choose one correct answer in the OMR sheet provided. No overwriting should be done.

(20 x 1 = 20 MARKS)

Time: 20 Minutes

• 1. Drug of choice for hypertension in eclampsia is

• a) Nifedipine

• b) MgSO4

• c) Labetalol

• d) Hydralazine

• 2. Bisacodyl is

• a) Stool softener

• b) Bulk laxative

• c) Osmotic purgative

• d) Stimulant purgative

• 3. What is the major mechanism of action of propylthiouracil in hyperthyroidism

• a) Inhibits iodine uptake

• b) Inhibits the hormone release

• c) Inhibit the enzyme thyroid peroxidase

• d) Helps in peripheral conversion of T4 to T3

• 4. Amphotericin B toxicity can be reduced by

• a) Combining with fluconazole

• b) Combining with flucytosine

• c) Injecting the drug with dextrose

• d) Incorporating it in liposomal complex

• 5. Which of the following drug is contraindicated in a case of bilateral renal artery stenosis?

• a) Enalapril

• b) Hydralazine

• c) Dopamine

• d) Methyldopa

• 6. Which of the following drugs has both 5HT4 agonist and D2 antagonist property

• a) Abutilide

• b) Ondansetron

• c) Metoclopramide

• d) Benzhexol

• 7. Mechanism of action of oseltamivir is:

• a) Blocks M2 protein

• b) Neuraminidase inhibitor

• c) Block DNA dependent RNA polymerase

• d) Apoptosis of respiratory epithelial cells

• 8. Atorvastatin acts by which of the following mechanism

• a) Bile acid sequestrant

• b) Lipoprotein lipase inhibitor

• c) Cholesterol absorption inhibitor

• d) HMG-CoA reductase inhibitor

• 9. Antihelminthic also acting as immunomodulator is

• a) Levamisole

• b) Albendazole

• c) Piperazine

• d) Mebendazole

• 10. Finasteride is used for the treatment of

• a) Benign prostatic hyperplasia

• b) Impotence

• c) Depression

• d) Gynecomastia

• 11. Most specific antiemetic for chemotherapy induced vomiting

• a) Tegaserod

• b) Granisetron

• c) Doxylamine

• d) Metoclopramide

• 12. Most important dose-limiting toxicity of cancer chemotherapy is:

• a) Neurotoxicity

• b) Gastrointestinal toxicity

• c) Nephrotoxicity

• d) Bone marrow suppression

• 13. True about vitamin K is:

• a) Long term use of antimicrobials can cause deficiency of vitamin K

• b) It is required for synthesis of clotting factor VII

• c) It is a water soluble vitamin

• d) DVT is associated with vitamin K deficiency

• 14. Mechanism of action of Linezolid is:

• a) Binds to 50S ribosome and inhibits Met-tRNA initiation complex

• b) Binds to 30S ribosome and inhibits Met-RNA initiation complex

• c) Inhibits peptidyl transferase

• d) Inhibits attachment of aminoacyl tRNA to A-site

• 15. Octreotide is used for

• a) Osteoarthritis

• b) Acromegaly

• c) Pancreatitis

• d) Constipation

• 16. Which is not an antiplatelet drug?

• a) Streptokinase

• b) Aspirin

• c) Ticlopidine

• d) Clopidogrel

• 17. Furosemide causes

• a) Respiratory alkalosis

• b) Metabolic alkalosis

• c) Respiratory acidosis

• d) Metabolic acidosis

• 18. Absolute contraindication to thrombolytic therapy is

• a) History of hemorrhagic stroke in past one year

• b) Pregnancy

• c) Hypertension

• d) Patients on nitrates

• 19. False statement about racecadotril is:

• a) It is a drug used in constipation

• b) It is a prodrug that is converted to peripherally acting enkephalinase inhibitor

• c) It has anti-secretory action in GIT

• d) It is metabolised by liver

• 20. Which of the following statements about erythropoietin is FALSE?

• a) It results in decrease in reticulocyte count

• b) It is used for the treatment of anemia due to chronic renal failure

• c) It can cause hypertension

• d) It decreases the requirement of blood transfusions

ATAL BIHARI VAJPAYEE MEDICAL UNIVERSITY, LUCKNOW MBBS DEGREE - IInd PROFESSIONAL - SUPPLEMENTARY EXAMINATION - JUNE 2024

PHARMACOLOGY - PAPER - II

TIME: 3 Hrs Max. Marks: 100 Marks (80 Theory + 20 MCQs)

NOTE:

• Attempt all questions.

• This question paper consists of two sections: Section A- Multiple Choice Questions and Section B- Theory Questions.

• Both the section has different paper code. Write correct paper code on respective sheet

• Write correct MCQ paper set on OMR sheet

• Answer MCQs on the provided OMR sheet and theory questions on the provided answer booklet

SECTION B - THEORY QUESTIONS

PAPER CODE: 2412230005

Q.1 Long Answer Question. ( 15 MARKS )

i) Classify oral hypoglycemic drugs. 4 marks

ii) Describe mechanism of action of sulfonylureas. 4 marks

ii) Explain pharmacology of sulfonylureas. 7 marks

Q.2 Clinical Case Scenario based Structured Question (15 MARKS)

A 30-years-old pregnant female consults for weakness, fatigue and occasional giddiness for the last 1 month. Blood testing showed Hb to be 7.6 g/dl, haematocrit was 27%, RBCs were microcytic-hypochromic, and other values were consistent with iron deficiency anaemia.

i) Mention different iron preparations. 4 mark

ii) Explain elemental iron with suitable example. 3 mark

iii) What are the indications for parenteral iron therapy? 3 mark

iv) Describe adverse effects of parenteral iron in detail. 5 mark

Q.3 Short Note Question (Approx 500 Words) 5 X 6 = 30 MARKS

i) Loop diuretics

ii) Management of congestive heart failure

iii) Management of urinary tract infection

iv) Classify cephalosporin drugs

v) Proton pump inhibitors

Q.4 Short Answer Questions (Within 100 Words) 5 X 4 = 20 MARKS

i) Why clavulanic acid is added with amoxycillin?

ii) Write the rational for combining sulfamethoxazole with trimethoprim

iii) Why Thyroxine hormone preparation should be given in empty stomach preferably during morning hours.

iv) Mechanism of action and adverse effects of tetracyclines

v) Chelating agents

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