Pharmacology Paper-2 (Supplementary), 2020 MBBS Batch ABVMU Lucknow

ATAL BIHARI VAJPAYEE MEDICAL UNIVERSITY, LUCKNOW

MBBS IInd PROFESSIONAL - SUPPLEMENTARY EXAMINATION - FEB-2023

PHARMACOLOGY-PAPER-II

TIME: 3 Hrs

Max. Marks: 100

Note: Attempt all questions. Answer PART- A and PART - B in separate answer books. All part of a question should be answered together.

PART-A

PAPER CODE: 2322130005

Q.1 Long Answer Question (5+5+5=15 Marks)

A 40-year male working in corporate presents in OPD with burning in the chest with dull epigastric pain for 2 months. The pain aggravated 2 hours after taking the food and sometime awakens him at night. Upper gastrointestinal endoscopy reveals an ulcer in the duodenum. He has diagnosed a case of Duodenal Ulcer. Based on the case scenario give the answer to following questions:

a) Give classification of drugs available for the treatment of peptic ulcer.

b) Briefly discuss the pharmacology of proton pump inhibitors with the mechanism of action, site of action and adverse drug reactions.

c) Discuss Anti H.Pylori regimens used in Peptic Ulcer Disease.

Q.2 Short Notes Questions (within 500 words) (3 x 5 = 15 Marks)

a) Give rationale why clavulanic acid is added to Amoxycillin.

b) Uses of Prokinetic drugs in clinical practice.

c) Briefly discuss the pharmacotherapy of urinary tract infection?

Q.3 Short Answer Questions (within 100 words) (5 x 2 = 10 Marks)

a) Give rationale of using Nitroglycerine in angina by sublingual route.

b) Uses of Acetzolamide.

c) Write current status of Digoxin in Congestive Heart Failure & its adverse effects.

d) Mechanism of action of fluoroquinolone.

e) Explain why penicillin & Probenecid is given together to a patient suffering from gonorrhoea.

Q.4 Multiple Choice Question: (10 x 1 = 10 Marks)

1. A person has to go Shimla next morning. What drugs should be given to prevent motion sickness in this person?

a) Fexofenadine. b) Ranitidine one night before the trip. c) Dimenhydrinate 2 hour before journey d) Omeprazole half an hour before the trip.

2. All are H2 Blockers, Except:

a) Cimetidine b) Famotidine c) Ranitidine d) Omeprazole

3. Which of the following drugs acts by inhibiting cell wall synthesis:

a) Cefixime b) Amikacin c) Ceftriaxone d) Ciprofloxacin

4. Which of the following drugs are Not used in Typhoid fever:

a) Erythromycin b) Chloramphenicol c) Sulfonamides d) Cephalosporins

5. A bactericidal drug would be preferred over a bacteriostatic drug in a patient with:

a) Cirrhosis b) Pneumonia c) Neutropenia d) Heart disease

6. Iron poisoning is commonly treated by:

a) Dimeracaprol b) Calcium disodium EDTA c) Desferrioxamine d) Deferiprone

7. Methotrexate is:

a) Purine antagonist b) Folic acid antagonist c) Antibiotic d) Alkylating agent

8. Drug of choice for scrub typhus is:

a) Azithromycin b) Ciprofloxacin c) Doxycycline d) Chloramphenicol

9. The antibiotic which can be given safely in a pregnant women is:

a) Ciprofloxacin b) Cefuroxime c) Metronidazole d) Chloramphenicol

10. Which of the following is calcineurin inhibitor?

a) Cyclosporine b) Methotrexate c) Azathioprine d) Mycophenolate mofetil

PART-B PAPER CODE: 2322230005

Q.1 Long Answer Question (5+5+5=15)

A 60 year old factory worker presents in OPD with the complains of cough, expectoration, mild chest pain and fatigue for past 2 months. He has given the history of mild fever for last one week. The patient has been diagnosed a case of tuberculosis (chest X-ray showed a cavitary lesion in right middle lobe and fibrotic changes with increased bronchovascular markings both the sides). Based on this case scenario answer the following questions:

a) What are the goals of pharmacotherapy for this patient?

b) Enumerate first line and second line antitubercular medications.

c) Adverse effects of Rifampicin, Isoniazid and Ethambutol.

Q.2 Short Notes Questions (within 500 words) (3 x 5 = 15 Marks)

a) Briefly discuss pharmacotherapy of urinary tract infection.

b) Explain the role of autonomy and shared responsibility as a guiding principle in patient care.

c) Briefly discuss the use of antimicrobials in typhoid fever.

Q.3 Short Answer Questions (within 100 words) (5 x 2 = 10 Marks)

a) Give rationale of combination of pyrimethamine with sulphadoxine.

b) Give reasons why multidrug therapy is indicated in leprosy.

c) Give justification why loperamide should not be used for infective diarrheas.

d) Role of Bisphosphonates in Osteoporosis.

e) Write briefly the indications of parenteral uses of iron.

Q.4 Multiple Choice Question: (10 x 1 = 10 Marks)

1. Drug of choice for pregnancy induced hypertension is:

a) Methyldopa b) Atenolol c) Nitroprusside d) Enalapril

2. Calcium channel blockers are used in all, Except:

a) Angina b) Arrhythmia c) Congestive heart failure d) Hypertension

3. A sixteen year old girl is found to have paroxysmal attacks of rapid heart rate. The antiarrhythmic of choice in most cases of acute AV nodal tachycardia is:

a) Adenosine b) Amiodarone c) Propranolol d) Quinidine

4. Which one of the following drug is used in treatment of herpes virus infection:

a) Zidovudine b) Valacyclovir c) Lamivudine d) Azacitidine

5. Cough and angioedema in a patient receiving ACE inhibitors is due to:

a) Bradykinin b) Renin c) Angiotensin-II d) All

6. Which diuretic could be considered appropriate for combining with ACE inhibitors:

a) Spironolactone b) Eplerenone c) Hydrochlorothiazide d) Amiloride

7. Drug of choice for bleeding oesophageal varices is:

a) Ethanolamine b) Octreotide c) Propranolol d) Phytonadione

8. Which of the following is used mainly to lower post prandial blood glucose levels?

a) Sitagliptin b) Acarbose c) Repaglinide d) Sulfonylurea

9. The most potent topical corticosteroid is:

a) Betamethasone b) Triamcinolone c) Hydrocortisone d) Clobetasol butyrate

10. Side effects of oral contraceptives are all, Except:

a) Irregular bleeding b) Headache c) Thrombosis d) Increased risk of ovarian cancer

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