Pharmacology Paper-1 (Supplementary), 2020 MBBS Batch ABVMU Lucknow

ATAL BIHARI VAJPAYEE MEDICAL UNIVERSITY, LUCKNOW

MBBS IInd PROFESSIONAL - SUPPLEMENTARY EXAMINATION - FEB-2023

PHARMACOLOGY-PAPER-I

TIME: 3 Hrs Max. Marks: 100

Note: Attempt all questions. Answer PART- A and PART-B in separate answer books. All parts of a question should be answered together.

PART-A PAPER CODE: 2321130005

Q.1 Long Answer Question (5+5+3+2=15 Marks)

A 70-year-old man presented in medicine OPD with difficulty in maintaining posture tremors of the hands and a mask-like face. He was diagnosed with a case of Parkinsonism. Based on this case scenario, answer the following questions:

• What are the different classes of drugs available for the treatment of Parkinsonism?

• Brief mechanism of various antiparkinsonian drugs.

• Adverse effects of antiparkinsonian drugs.

• Advantage of using a combination of Levodopa & Carbidopa.

Q.2 Short Notes Questions (within 500 words) (3 x 5 = 15 Marks)

• Therapeutic drug monitoring.

• Drug treatment of myasthenia gravis.

• Pharmacotherapy of acute congestive glaucoma.

Q.3 Short Answer Questions (within 100 words) (5 x 2 = 10 Marks)

• Advantages of writing generic names in prescription writing.

• Rationale for not using beta-blockers in asthma.

• Drugs used in the prophylaxis of motion sickness.

• Selective Cox-2 inhibitors.

• Microsomal enzyme induction.

Q.4 Multiple Choice Question: (10 x 1 = 10 Marks)

• 1. From which of the following routes, the bioavailability of the drug is likely to be 100%:

• (a) Intravenous

• (b) Subcutaneous

• (c) Intramuscular

• (d) Intradermal

• 2. Which of the following is a schedule-X drug:

• (a) Thalidomide

• (b) Colistin

• (c) Ketamine

• (d) Paracetamol

• 3. Phase-4 clinical trial is carried out:

• (a) Before the marketing approval

• (b) After the drug is marketed

• (c) For drugs used in rare diseases

• (d) For drugs used in pediatric patients

• 4. Which of the following drugs is used in the prophylaxis of motion sickness:

• (a) Metoclopramide

• (b) Prochlorperazine

• (c) Ondansetron

• (d) Hyoscine

• 5. Most common adverse effect of Salbutamol is:

• (a) Tremors

• (b) Hypertension

• (c) Rhinorrhoea

• (d) Headache

• 6. Which of the following is not a cardioselective beta-blocker:

• (a) Metoprolol

• (b) Propranolol

• (c) Bisoprolol

• (d) Atenolol

• 7. Beta-blockers are indicated in all of the following conditions Except:

• (a) Hypothyroidism

• (b) Alcohol withdrawal

• (c) Performance anxiety

• (d) Portal hypertension

• 8. Which of the following is Not a second-generation antihistaminic?

• (a) Cetirizine

• (b) Pheniramine

• (c) Fexofenadine

• (d) Loratidine

• 9. The antidote of choice in Paracetamol poisoning is:

• (a) Flumazenil

• (b) Sodium bicarbonate

• (c) N-acetylcysteine

• (d) Methylene Blue

• 10. Drug useful for chronic gout is:

• (a) Pyrazinamide

• (b) Rifampicin

• (c) Naloxone

• (d) Allopurinol

ATAL BIHARI VAJPAYEE MEDICAL UNIVERSITY, LUCKNOW

MBBS IInd PROFESSIONAL - SUPPLEMENTARY EXAMINATION - FEB-2023

PHARMACOLOGY-PAPER-I

TIME: 3 Hrs Max. Marks: 100

Note: Attempt all questions. Answer PART- A and PART-B in separate answer books. All parts of a question should be answered together.

PART-B PAPER CODE: 2321230005

Q.1 Long Answer Question (5+6+4=15 Marks)

A lady aged with 55 yrs was brought at night to the hospital emergency with severe breathlessness and wheezing. Chest auscultation revealed marked bronchoconstriction. She was diagnosed a case of asthma. Based on the case scenario answer the following question

What are the various class of drug for bronchial asthma?

Briefly describe mechanism of action of methyl xanthines and its adverse drug reactions.

Discuss the role of corticosteroids in Status asthmaticus.

Q.2 Short Notes Questions (within 500 words) (3 x 5 = 15 Marks)

• Briefly describe different phases of drug development process.

• Briefly describe various uses and adverse effects of Aspirin.

• Briefly describe the drug treatment of status epilepticus.

Q.3 Short Answer Questions (within 100 words) (5 x 2 = 10 Marks)

• Difference between loading dose and maintenance dose of a drug.

• Why atropine is used in pre anaesthetic medication?

• Adverse effects of beta blockers.

• Rationale of using adrenaline in anaphylaxis.

• Explain why Morphine should not be prescribed for head injury cases.

Q.4 Multiple Choice Question: (10 x 1 = 10 Marks)

• 1. Drug of choice for drug induced parkinsonism is:

• (a) Levodopa

• (b) Amantadine

• (c) Benzhexol

• (d) Carbidopa

• 2. A patient presented with pain in the right lower quadrants of abdomen. He has history of renal stones in right kidney. He was prescribed an opioid which is agonist at kappa receptors and antagonist at mu receptors. The likely drug given was:

• (a) Pentazocine

• (b) Buprenorphine

• (c) Tramadol

• (d) Fentanyl

• 3. Characteristic feature of opioid withdrawal is:

• (a) Rhinorrhea and lacrimation

• (b) Seizures

• (c) Delirium Tremors

• (d) Transient tactile or auditory hallucination

• 4. Loading dose of a drug is given:

• (a) To achieve steady state concentration

• (b) For drugs with short half life

• (c) To reduce complications

• (d) All of the above

• 5. Most variable absorption is seen with which route?

• (a) Intramuscular

• (b) Per rectal

• (c) Oral

• (d) Intravenous

• 6. Atropine is used in all except:

• (a) Glaucoma

• (b) As mydriatric

• (c) As a cycloplegic

• (d) In Preanaesthetic medication

• 7. All of the following are ototoxic drugs Except:

• (a) Cisplatin

• (b) Paracetamol

• (c) Aminoglycosides

• (d) Loop diuretics

• 8. Benzodiazepines acts on:

• (a) Beta-2 receptors

• (b) Calcium channels

• (c) Alpha receptors

• (d) GABA A receptors

• 9. Which of the following drug is used to treat status epilepticus?

• (a) Primidone

• (b) Carbamazepine

• (c) Lorazepam

• (d) Sodium Valproate

• 10. Which of the following is a bronchodilator:

• (a) Corticosteroids

• (b) Salmeterol

• (c) Ketotifen

• (d) Sodium Cromoglycate

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