Pharmacology Paper-1 (Main), 2022 MBBS Batch ABVMU Lucknow

MBBS DEGREE - IInd PROFESSIONAL - REGULAR EXAMINATION - DEC 2024 PHARMACOLOGY - PAPER - I

SECTION A - Multiple Choice Questions (MCQs)

PAPER CODE: 2411130005

SET: A

Note: Choose one correct answer in the OMR sheet provided. No overwriting should be done.

(20 x 1 = 20 MARKS)

Time: 20 Minutes

1. Which of the following is a P glycoproteins inducer?

a) Erythromycin b) Rifampicin c) Ketoconazole d) Itraconazole

2. NSAID with least anti-inflammatory action is

a) Ketorolac b) Paracetamol c) Ibuprofen d) Indomethacin

3. Drug of choice for prophylaxis of acute mountain sickness:

a) Diltiazem b) Digoxin c) Acetazolamide d) Dexamethasone

4. Drug used for smoking cessation is:

a) Varenicline b) Acamprosate c) Naloxone d) Sildenafil

5. Which of the following act through G protein coupled receptors?

a) Muscarinic receptors b) Insulin receptors c) Nicotinic receptors d) GABA-A receptors

6. From which of the following routes, bioavailability of the drug is likely to be 100 percent?

a) Intravenous b) Subcutaneous c) Intradermal d) Intramuscular

7. Drugs used in prophylaxis of migraine are all except?

a) Sumatriptan b) Valproate c) Propranolol d) Topiramate

8. Which of the following drugs cause oligospermia?

a) Leflunomide b) D-Penicillamine c) Sulfasalazine d) Methotrexate

9. All of the following agents are used in glaucoma treatment, except:

a) Pilocarpine b) Timolol c) Metoprolol d) Apraclonidine

10. Anti-Parkinson's drug known to cause cardiac valvular fibrosis is

a) Levo-dopa b) Ropinirole c) Pergolide d) Pramipexole

11. Anticonvulsant causing visual field contraction is

a) Vigabatrin b) Ethosuximide c) Levetiracetam d) Phenytoin

12. Drug of choice in complex partial seizure is:

a) Phenytoin b) Valproate c) Phenobarbitone d) Carbamazepine

13. Which of the following drugs is not used in Rheumatoid arthritis?

a) Febuxostat b) Leflunomide c) Etanercept d) Methotrexate

14. Which of the following does not have a role in acute attack of asthma?

a) Cromolyn sodium b) Ipratropium c) Steroids d) Salbutamol

15. Which drug used for differentiating myasthenia gravis from cholinergic crisis?

a) Edrophonium b) Labetelol c) Clonidine d) Salbutamol

16. Which of the following drugs act by inhibiting granulocyte migration?

a) Colchicine b) Montelukast c) Cromoglycate d) Allopurinol

17. Injection of all of the following drugs is painful except

a) Propofol b) Etomidate c) Ketamine d) Methohexitone

18. All of the following are side effect of ropinirole except

a) Sedation b) Nausea c) Retroperitoneal Fibrosis d) Hallucination

19. Which of the following is not an adverse effect of salbutamol?

a) Hypoglycemia b) Hypokalemia c) Tremors d) Tachycardia

20. Mechanism of action of theophylline in bronchial asthma include all of the following except

a) Phosphodiesterase inhibition b) Adenosine receptor antagonism c) Increased histone

deacetylation d) Beta-2 receptor stimulation

ATAL BIHARI VAJPAYEE MEDICAL UNIVERSITY

MBBS DEGREE - FINAL PROFESSIONAL - REGULAR EXAMINATION - DEC 2024 PHARMACOLOGY - PAPER - I

Max. Marks: 100 Marks (80 Theory + 20 MCQs)

TIME: 3 Hrs

NOTE:

Attempt all questions. This question paper consists of two sections: Section A- Multiple Choice Questions and Section B- Theory Questions. Both the section has different paper code. Write correct paper code on respective sheet.

Write correct MCQ paper set on OMR sheet.

Answer MCQs on the provided OMR sheet and theory questions on the provided answer booklet.

SECTION B - THEORY QUESTIONS

PAPER CODE: 2411230005

Q.1 Long Answer Question. ( 15 MARKS )

(i) Classify Anticholinesterases. 3 marks

(ii) Discuss the mechanism of action and indications of reversible Anti-cholinesterases. 4 marks

(iii) What are Nerve Gases, and where are they used? 2 marks

(iv) Outline the management of acute Organophosphorous poisoning. 6 marks

Q.2 Clinical Case Scenario based Structured Question (15 MARKS)

A 25-year-old male with symptoms of excessive fatigue and lack of sleep was brought to the clinic. His relatives say that he is socially withdrawn and has made two attempts of suicide. He was prescribed tab fluoxetine.

(i) Explain the mechanism of action, uses and adverse effects of fluoxetine. 3 marks

(ii) Why Fluoxetine takes a long time to show its clinical effect? 4 marks

(iii) Classify other drugs useful in the above condition. 4 marks

(iv) What advantages do SSRIs have over TCAs for management of depression? 4 marks

Q.3 Short Note Question (Approx 500 Words) 5 X 6 = 30 MARKS

(i) Special drug delivery systems

(ii) Centrally acting cough suppressants and their use

(iii) Role of Doctors in Community

(iv) Advantages & disadvantages of 2nd Generation Antipsychotics.

(v) Elaborate Use of Nitrates and Beta blockers in Angina pectoris.

Q.4 Short Answer Questions (Within 100 Words) 5 X 4 = 20 MARKS

(i) Drug Antagonism with appropriate examples.

(ii) Uses & advantages of Newer Antiepileptic drugs

(iii) Cardiac & Non-Cardiac uses of Beta Blockers.

(iv) Mention two advantages and disadvantages of sublingual route of drug administration

(v) Dopaminergic agonist in Parkinsonism.

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