Pathology Paper-1 (Supplementary), 2021 MBBS Batch ABVMU Lucknow

ATAL BIHARI VAJPAYEE MEDICAL UNIVERSITY, LUCKNOW
MBBS DEGREE – IInd PROFESSIONAL – SUPPLEMENTARY EXAMINATION – JUNE 2024
PATHOLOGY - PAPER I
SECTION A - Multiple Choice Questions (MCQs)

PAPER CODE: 2421130004
SET: D
Time: 20 Minutes (20 x 1 = 20 MARKS)

Note: Choose one correct answer in the OMR sheet provided. No overwriting should be done.

• 1. Anti Scl 70 antibodies are associated with
  a) Sheehan syndrome
  b) Sjogren syndrome
  c) Systemic lupus erythematosus
  d) Scleroderma

• 2. Hypersegmented neutrophils are present in which of the following anemia?
  a) Iron deficiency
  b) Hemolytic
  c) Megaloblastic
  d) Aplastic

• 3. Which complement fragments called as “Anaphylotoxins”?
  a) C3 & C4
  b) C3a & C3b
  c) C5a & C3a
  d) C3b & C5a

• 4. Wound contraction is mediated by
  a) Collagen
  b) Epithelial cells
  c) Myofibroblasts
  d) Elastin

• 5. Anaemia in humans can be caused by which of the following worms?
  a) Tape worm
  b) Round worm
  c) Bristle worm
  d) Hook worm

• 6. Barrett’s Oesophagus is example of
  a) Metaplasia
  b) Atrophy
  c) Dystrophy
  d) Dysplasia

• 7. An example of tumor suppressor gene
  a) FAS
  b) MYC
  c) RAS
  d) Rb

• 8. Which of the following is anti-apoptotic gene
  a) Bax
  b) P 53
  c) bid
  d) Bcl 2

• 9. Serum sickness is an example of this type of hypersensitivity reaction
  a) Type II
  b) Type I
  c) Type IV
  d) Type III

• 10. Gaucher’s disease is caused by deficiency of
  a) GM2 gangliosides
  b) Glucokinase
  c) Fructokinase
  d) Glucocerebrosidase

• 11. All are features of hemolytic anemia EXCEPT
  a) Bilirubinemia
  b) Hemoglobinemia
  c) Increased Haptoglobin
  d) Reticulocytosis

• 12. Which variant of Hodgkin’s lymphoma has worst prognosis
  a) Lymphocyte depleted
  b) Lymphocyte predominant
  c) Nodular sclerosis
  d) Mixed cellularity

• 13. The correct sequence of cell cycle is
  a) G0 – G1 – G2 - S - M
  b) G0 – G1 – S - G2 - M
  c) G0 – M - G1 – G2 - S
  d) G0 - S - G1 - G2 - M

• 14. Transformation of one type of mature epithelium into another type of mature epithelium is
  a) Anaplasia
  b) Dysplasia
  c) Hyperplasia
  d) Metaplasia

• 15. Heart failure cells are found in
  a) Liver
  b) Heart
  c) Lung
  d) Kidney

• 16. Diabetic foot is an example of
  a) Wet gangrene
  b) Dry gangrene
  c) Apoptosis
  d) Gas gangrene

• 17. The most effective Antigen presenting cells (APCs) are
  a) Neutrophils
  b) Dendritic cells
  c) NK cells
  d) Lymphocytes

• 18. Christmas factor is
  a) VIII
  b) VII
  c) X
  d) IX

• 19. Term “Wear & tear pigment” refers to
  a) Melanin
  b) Lysozyme
  c) Anthracotic pigment
  d) Lipofuscin

• 20. Caspases are involved in mechanism of
  a) Atherosclerosis
  b) Necrosis
  c) Inflammation
  d) Apoptosis

ATAL BIHARI VAJPAYEE MEDICAL UNIVERSITY, LUCKNOW
MBBS DEGREE - IInd PROFESSIONAL - SUPPLEMENTARY EXAMINATION - JUNE 2024
PATHOLOGY - PAPER I

TIME: 3 Hrs
Max. Marks: 100 Marks (80 Theory + 20 MCQs)

NOTE:

• Attempt all questions.

• This question paper consists of two sections: Section A- Multiple Choice Questions and Section B- Theory Questions.

• Both the sections have different paper codes. Write correct paper code on respective sheet.

• Write correct MCQ paper set on OMR sheet.

• Answer MCQs on the provided OMR sheet and theory questions on the provided answer booklet.

SECTION B - THEORY QUESTIONS

PAPER CODE: 2421230004

Q.1 Long Answer Question 15 MARKS
i) Define shock. 3 marks
ii) Describe the different kinds of shock using appropriate examples. 6 marks
iii) Give an example of the pathophysiology of septic shock using a flowchart. 6 marks

Q.2 Clinical Case Scenario based Structured Question

15 MARKS
A 65-year-old female is admitted with worsening anemia and pathological fracture of femur. Her X-ray skull shows punched out osteolytic lesions.
i) What is the probable diagnosis? 2 marks
ii) Describe the pathophysiology of the disease. 5 marks
iii) Discuss relevant laboratory investigations to confirm the diagnosis. 5 marks
iv) What are the complications of this disease? 3 marks

Q.3 Short Note Questions (Within 500 Words)

5 × 6 = 30 MARKS
i) Lab diagnosis of Megaloblastic Anemia
ii) Communication with relatives of a patient diagnosed with malignancy on Pathology report
iii) Pre-transfusion testing
iv) Distinguish between wound healing by primary and secondary intention
v) Discuss the peripheral smear findings in chronic myeloid leukemia

Q.4 Short Answer Questions (Within 100 Words)

5 × 4 = 20 MARKS
i) Acute Vitamin-A toxicity
ii) Mention four X-linked recessive disorders
iii) Secondary Amyloidosis
iv) Mechanism of autoimmunity
v) Genetic abnormality in Down syndrome

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