Pathology Paper-1 (Main), 2022 MBBS Batch ABVMU Lucknow

ATAL BIHARI VAJPAYEE MEDICAL UNIVERSITY, LUCKNOW

MBBS DEGREE - IInd PROFESSIONAL - REGULAR EXAMINATION - DEC 2024

PATHOLOGY - PAPER - I

PAPER CODE: 2411130004

SECTION A - Multiple Choice Questions (MCQs)

Note: Choose one correct answer in the OMR sheet provided. No overwriting should be done.

SET: C

Time: 20 Minutes

(20 x 1 = 20 MARKS)

Which type of white blood cell is most likely to be elevated during an allergic reaction?

a) Lymphocytes b) Neutrophils c) Eosinophils d) Basophils

2. The key enzymes involved in the execution phase of apoptosis are:

a) Caspases b) Cyclins c) Kinases d) Ligases

3. Which of the following is NOT a cardinal sign of acute inflammation?

a) Redness b) Swelling c) Fever d) Pain

4. HIV primarily targets which cells of the immune system?

a) Neutrophils b) B lymphocytes c) Macrophages d) T lymphocytes

5. Sirtuins are a family of proteins involved in:

a) DNA repair b) Cellular senescence c) Metabolic regulation d) Oxidative stress

6. A 40-year-old woman presents with memory impairment, irritability, and abdominal pain. She lives in an old house with peeling paint. Blood tests reveal microcytic anemia. What is the most likely diagnosis?

a) Hemochromatosis b) Thalassemia c) Lead poisoning d) Mercury poisoning

7. Telomere shortening is associated with:

a) Increased cellular lifespan b) Cellular immortality c) Cellular senescence d) Enhanced DNA replication

8. Which of the following is an example of an autoimmune disease?

a) HIV/AIDS b) Tuberculosis c) Malaria d) Rheumatoid arthritis

9. Autophagy is a cellular process involved in:

a) Protein synthesis b) Cellular degradation c) DNA replication d) Cell cycle progression

10. Which of the following is a reversible cell injury?

a) Necrosis b) Apoptosis c) Cellular swelling d) Liquefactive necrosis

11. Chronic lymphocytic leukemia (CLL) is most commonly diagnosed in which age group?

a) Children b) Adolescents c) Young adults d) Older adults

12. Cystic fibrosis is caused by:

a) A single gene mutation b) A chromosomal abnormality c) Environmental factors d) Unknown factors

13. How is Fresh Frozen Plasma stored?

a) At room temperature b) Refrigerated at 2-8°C c) Frozen at -18°C or colder d) Lyophilized

14. Type II hypersensitivity reactions involve:

a) Antibody-mediated cell destruction b) Immune complex deposition c) T-cell mediated cytotoxicity d) Delayed-type hypersensitivity

15. A 25-year-old male presents with tall stature, gynecomastia, and small testes. Chromosomal analysis reveals 47, XXY. Which of the following features is most characteristic of his condition?

a) Intellectual disability b) Male infertility c) Cardiomegaly d) Microcephaly

16. Howell-Jolly bodies are seen in:

a) Iron deficiency anemia b) Hemolytic anemia c) Megaloblastic anemia d) Asplenia

17. The following is a hallmark of reversible cell injury:

a) Karyorrhexis b) Pyknosis c) Cytoplasmic eosinophilia d) Mitochondrial swelling

18. The mediator primarily responsible for pain during inflammation is:

a) Histamine b) Bradykinin c) Leukotriene B4 d) Tumor necrosis factor-alpha

19. Microangiopathic hemolytic anemia is associated with which of the following conditions:

a) Sickle cell anemia b) Thalassemia c) Disseminated intravascular coagulation d) Pernicious anemia

20. Pancytopenia with hypercellular marrow is characteristic of:

a) Myelofibrosis b) Aplastic anemia c) Paroxysmal nocturnal hemoglobinuria d) Myelodysplastic syndrome

ATAL BIHARI VAJPAYEE MEDICAL UNIVERSITY, LUCKNOW

MBBS DEGREE - IInd PROFESSIONAL - REGULAR EXAMINATION - DEC 2024

PATHOLOGY - PAPER - I

TIME: 3 Hrs Max. Marks: 100 Marks (80 Theory + 20MCQs)

NOTE:

Attempt all questions. This question paper consists of two sections: Section A- Multiple Choice Questions and Section B- Theory Questions. Both the section has different paper code. Write correct paper code on respective sheet Write correct MCQ paper set on OMR sheet Answer MCQs on the provided OMR sheet and theory questions on the provided answer booklet.

SECTION B - THEORY QUESTIONS

PAPER CODE: 2411230004

Q.1 Long Answer Question. ( 15 MARKS )

i) Define Thrombosis & enumerate the etiological factors for thrombosis (5 marks )

ii) Write in detail about pathogenesis, morphology & fate of thrombus.(10 marks)

Q.2 Clinical Case Scenario based Structured Question (15 MARKS)

50/Male presented with massive splenomegaly his total count was 2,35,000 cells per mm³ with preponderance of neutrophilic precursors. Platelet count was 5,80,000 cells per mm³.

i) What is your diagnosis? 2 marks

ii) Different investigation of blood? 2 marks

iii) What is the molecular basis of this disease? 3 marks

iv) Write about the microscopic morphological features in this peripheral smear and bone marrow. 5 marks

v) Classify myeloproliferative neoplasms. 3 marks

Q.3 Short Note Question (Approx 500 Words) 5 X 6 = 30 MARKS

i) Write about dystrophic and metastatic calcification.

ii) Describe events in pathogenesis of HIV infection.

iii) Glycogen storage

iv) Describe the importance of respect in relationship with patients, fellow team members, superiors and other health care worker? disorders.

v) Laboratory diagnosis of megaloblastic anemia.

Q.4 Short Answer Questions (Within 100 Words) 5 X 4 = 20 MARKS

i) Down's syndrome.

ii) Write factors affecting wound healing.

iii) Define hyperplasia and give two examples.

iv) Amyloidosis of spleen.

v) Describe obesity pathogenesis and its relation to cancer.

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