Microbiology Paper-1 (Main), 2021 MBBS Batch ABVMU Lucknow

ATAL BIHARI VAJPAYEE MEDICAL UNIVERSITY, LUCKNOW

MBBS DEGREE - II nd PROFESSIONAL - REGULAR EXAMINATION - MARCH 2024

MICROBIOLOGY - PAPER I

SECTION A - Multiple Choice Questions (MCQs)

PAPER CODE: 2411130006 SET: A

Time: 20 Minutes (20 x 1 = 20 MARKS)

Note: Choose one correct answer in the OMR sheet provided. No overwriting should be done.

1. Tyndallisation is a type of:
   a) Intermittent sterilization
   b) Pasteurisation
   c) Dry heat
   d) Boiling

2. Prozone phenomenon is due to:
   a) Antigen excess
   b) Antibody excess
   c) Hyperimmune response
   d) Antigen-antibody excess

3. Bacteria are uniformly stains in which phase of bacterial growth curve?
   a) Lag phase
   b) Log phase
   c) Stationary phase
   d) Decline phase

4. Which of the following uses both diffusion and dilution methods for antimicrobial susceptibility?
   a) Kirby Bauer
   b) Broth Dilution Method
   c) E-test
   d) Stokes

5. Which one is the single most important cause of gastroenteritis in young children?
   a) Adenovirus
   b) Rota viruses
   c) Norovirus
   d) Sapovirus

6. Definitive host for Echinococcus is:
   a) Man
   b) Sheep
   c) Dog
   d) Lunging genes

7. Penicillin anaphylaxis is mediated by which of the following hypersensitivity reactions?
   a) Type I
   b) Type II
   c) Type III
   d) Type IV

8. Detection of fimbriae can be done by which of the following method?
   a) Hanging drop method
   b) Gram’s stain
   c) Electron Microscope
   d) Differential Staining

9. What is a mutation that changes the whole sequence of amino acids occurring after it known as?
   a) Missense mutation
   b) Nonsense mutation
   c) Point mutation
   d) Frameshift mutation

10. Which is the most common cause of endocarditis associated with intravenous drug abusers ?
    a) Staphylococcus epidermitis
    b) Streptococcus agalactiae
    c) Staphylococcus aureus
    d) Streptococcus pneumoniae

11. Which of the following is NOT a suitable specimen for anaerobic culture ?
    a) Peritoneal fluid
    b) Throat swab
    c) Exudates from deep tissue
    d) Blood

12. Which of the following biochemical waste bags are terminally disposed by autoclave sterilization?
    a) Yellow
    b) Red
    c) Green
    d) White

13. A 25-year-old female presents with generalized edema, swelling, flushing tachycardia, and edema after a bee sting. This reaction is mediated by which of the following antibodies?
    a) IgM
    b) IgG
    c) IgA
    d) IgE

14. Endoscope is sterilized by:
    a) Glutaraldehyde
    b) Formaldehyde
    c) Hot air oven
    d) Autoclaving

15. Which level of hepatitis B antibody is considered to be protective after vaccination?
    a) 0.1 IU/ml
    b) 1 IU/ml
    c) 10 IU/ml
    d) 0.05 IU/ml

16. Which of the following is an Enveloped viruses :
    a) Herpes virus
    b) Adenovirus
    c) Influenza virus
    d) Polio virus

17. All of the following are testing methods of antimicrobial sensitivity for bacteria EXCEPT:
    a) Disk diffusion method
    b) Broth dilution method
    c) Chemical method
    d) Molecular method

18. Which of the following fungi is usually associated with Blood Stream Infection?
    a) Sporothrix schenckii
    b) Paracoccidioides
    c) Piedra
    d) Rhizopus

19. India ink is which type of staining technique?
    a) Simple Staining
    b) Impregnation Method
    c) Negative Staining
    d) Differential Staining

20. Jumping genes is

    a) Transposon

    b) Episone

    c) Cosmid

    d) Plasmid

ATAL BIHARI VAJPAYEE MEDICAL UNIVERSITY, LUCKNOW

MBBS DEGREE - IInd PROFESSIONAL - REGULAR EXAMINATION - MARCH 2024

TIME: 3 Hrs MICROBIOLOGY - PAPER - I Max. Marks: 100 Marks (80 Theory + 20MCQs)

NOTE:

• Attempt all questions.

• This question paper consists of two sections: Section A - Multiple Choice Questions and Section B - Theory Questions.

• Both the section has different paper code. Write correct paper code on respective sheet

• Write correct MCQ paper set on OMR sheet

• Answer MCQs on the provided OMR sheet and theory questions on the provided answer booklet.

SECTION B - THEORY QUESTIONS

PAPER CODE: 2411230006

Q.1 Long Answer Question. ( 15 MARKS )

i) Define sterilization. 2 marks

ii) Classify the various methods of sterilization. 4 marks

iii) Write the principle, functioning and sterilization control of an autoclave. 9 marks

Q.2 Clinical Case Scenario based Structured Question (15 MARKS)

A 44-year-old man visits the out patient department with complains of fever associated with chills and rigors occurring every 48 hours since 5 days, headache and vomiting that came down with profuse sweating. On examination mild jaundice, splenomegaly and hepatomegaly was found.

i) What is the most probable diagnosis? 2 marks

ii) Briefly discuss life cycle of the organism. 6 marks

iii) Explain its laboratory diagnosis. 7 marks

Q.3 Short Note Question (Approx 500 Words) 5 X 6 = 30 MARKS

i) Define antibody. Describe in detail about structure and function of Immunoglobulin M (IgM).

ii) Discuss in detail about the laboratory diagnosis of Hepatitis B virus infection.

iii) Write pathogenesis and laboratory diagnosis of Enteric fever.

iv) Acute Rheumatic fever.

v) Morphological classification of fungi.

Q.4 Short Answer Questions (Within 100 Words) 5 X 4 = 20 MARKS

i) Spaulding's classification of medical devices.

ii) Plasmid.

iii) Difference between innate and acquired immunity.

iv) Methicillin resistance staphylococcus aureus (MRSA).

v) Write the differences between exotoxin and endotoxin

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