Microbiology Paper-1 (Main), 2020 MBBS Batch ABVMU Lucknow

ATAL BIHARI VAJPAYEE MEDICAL UNIVERSITY, LUCKNOW

MBBS IInd PROFESSIONAL EXAMINATION - NOV -2022 SUBJECT: MICROBIOLOGY PAPER-I

Time: 3 Hrs

Max. Marks: 100

Note: Attempt all questions. Answer PART- A and PART - B in separate answer books. All part of a question should be answered together.

PART-A

PAPER CODE: 2211130006

Q.1 Long Answer Question (2+3+5+5=15)

A 65-year-old male was admitted to a hospital with complaints of severe pain in the lateral aspect of his right thigh and a small amount of pus discharge from the ingrown hair. On physical examination, the local area was found to be red, warm, and tender. Aspirated pus was subjected to Gram stain and showed Gram-positive cocci in clusters. Culture on blood agar showed golden yellow pigmented beta-hemolytic colonies.

a) What is clinical diagnosis and its causative organism?

b) List the infections caused by this organism.

c) Describe the virulence factors of this organism.

d) Briefly discuss the laboratory diagnosis.

Q.2 Short Notes Questions (within 500 words) (5x3=15)

a) Gram-positive cocci infections.

b) Difference between bacterial endotoxins and exotoxins.

c) Importance of confidentiality pertaining to patient identity on lab results.

d) Graft versus host reaction.

e) Differences between Disinfection and Sterilization

Q.3 Short Answer Questions (within 100 words) (2x5=10)

a) Superantigens.

b) Immune complex mediated hypersensitivity reactions.

c) Chronic granulomatous disease.

Q.4 Multiple Choice Questions (1 x 10 = 10)

1. A patient who recently returned from camping in the forest presents with malabsorption diarrhea. How does the most likely agent cause the diarrhea?

   (a) Co-infection with bacteria (b) Enterotoxin production (c) Suction disk attachment (d) Tissue invasion leading to an inflammatory response and prostaglandin production

2. The most effective way of preventing tetanus is:

   (a) Hyperbaric oxygen (b) Tissue debridement (c) Tetanus toxoid (d) Antibiotic

3. Aerosol Transmission occurs in all except:

   (a) Mycobacterium tuberculosis (b) Pneumococcus (c) Measles virus (d) Varicella (chickenpox and zoster)

4. "Malignant pustule" is a term used for:

   (a) An infected melanoma (b) A carbuncle (c) A rapidly spreading rodent ulcer (d) Anthrax of the skin

5. If bacteriological examination of CSF is expected to be delayed then it is stored as:

   (a) It is frozen (b) It is kept at 37°C (c) It is kept at room temperature (d) Sample is discarded

6. Which antigen persists in Salmonella carrier state?

   (a) H antigen (b) M antigen (c) O antigen (d) Vi antigen

7. Which of the following waste should be pre-treated on-site as per Bio Medical Waste Management guidelines 2016?

   (a) Expired/discarded medicines (b) Chemical solid waste (c) Microbiology, other clinical (d) Sharp waste

8. Number of Moments in Hand Hygiene as per World Health Organization is:

   (a) 4 (b) 5 (c) 6 (d) 10

9. Dermatophyte that does not affect nail:

   (a) Trichophyton (b) Epidermophyton (c) Microsporum (d) Candida albicans

10. Which of the following site is most commonly affected by Corynebacterium diphtheriae:

(a) Skin (b) Conjunctiva (c) Faucial (d) Kidney

ATAL BIHARI VAJPAYEE MEDICAL UNIVERSITY, LUCKNOW

MBBS IInd PROFESSIONAL EXAMINATION - NOV -2022 SUBJECT: MICROBIOLOGY PAPER-I

Time: 3 Hrs

Max. Marks: 100

Note: Attempt all questions. Answer PART- A and PART - B in separate answer books. All part of a question should be answered together.

PART-B

PAPER CODE: 2211130006

Q.1 Long Answer Question (2+3+5+5=15)

A 6 year old boy was admitted to the hospital with complaints of high grade fever, headache, vomiting, altered mental status, seizure and neck rigidity. CSF was collected by lumbar puncture in a sterile container and sent to Microbiology lab.

(a) What is the probable clinical diagnosis?

(b) Enlist the bacterial etiological agents of this disease

(c) What is the pathogenesis of this disease?

(d) Briefly discuss the laboratory diagnosis

Q.2 Short Notes Questions (within 500 words) (5x3=15)

a) Personal Protective Equipments

b) Standard tests for Syphillis.

c) Bacterial zoonotic infections

Q.3 Short Answer Questions (within 100 words) (2x5=10)

a) Enlist types of Culture media

b) Difference between active and passive immunity

c) Life cycle of Chlamydia

d) Bacterial aetiological agents of Urinary tract Infections

e) Adjuvants

Q.4 Multiple Choice Questions (1 x 10 = 10)

• 1. A 32 year old male has got clean wound without laceration. He had a booster dose of TT 6 years ago. What is the next line of management?

• (a) Wound care with single dose of tetanus toxoid

• (b) Wound care with human tetanus Ig with tetanus toxoid

• (c) Wound care with complete course of tetanus toxoid

• (d) Wound care with no immunization

• 2. Which of the following is not a cause of neonatal meningitis?

• (a) Escherichia coli

• (b) Streptococcus agalactia

• (c) Listeria monocytogenes

• (d) Streptococcus pneumonia

• 3. Which culture medium is preferred for culture of urine specimens?

• (a) TCBS agar

• (b) CLED agar

• (c) Chocolate agar

• (d) XLD agar

• 4. Causes of Non gonococcal urethritis are all, Except:

• (a) Chlamydia trachomatis

• (b) Herpes simplex virus

• (c) Candida albicans

• (d) Treponema pallidum

• 5. Plague is transmitted by:

• (a) Rat flea

• (b) Soft tick

• (c) Hard tick

• (d) Louse

• 6. Hand rub should NOT be used in which condition

• (a) Before touching patient

• (b) After touching patient

• (c) After touching patient surroundings

• (d) Hands are visibly soiled

• 7. Which of the following disinfectants is NOT used currently for disinfection of operation theatres?

• (a) Formaldehyde

• (b) Glutaraldehyde based compound

• (c) Hydrogen peroxide based compound

• (d) Quaternary ammonium compound

• 8. Solid waste items contaminated with blood and body fluids including cotton dressings belong to which category of biomedical waste?

• (a) Yellow

• (b) Red

• (c) Blue

• (d) White

• 9. The decreasing order of risk of transmission following occupational exposure:

• (a) HIV > HBV > HCV

• (b) HBV > HIV > HCV

• (c) HBV > HCV > HIV

• (d) HCV > HBV > HIV

• 10. Which of the following agent of meningitis can grow on chocolate agar but not on blood agar?

• (a) Neisseria meningitidis

• (b) Haemophilus influenzae

• (c) Moraxella catarrhalis

• (d) Escherichia coli

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