Biochemistry Paper-2 (Supplementary), 2023 MBBS Batch ABVMU Lucknow

ATAL BIHARI VAJPAYEE MEDICAL UNIVERSITY
MBBS DEGREE EXAMINATION – 1ST PROFESSIONAL-SUPPLEMENTARY EXAM – DEC 2024
BIOCHEMISTRY – PAPER II
SECTION A – Multiple Choice Questions (MCQs)
SET: A
PAPER CODE: 2422130003

Note: Choose one correct answer in the OMR sheet provided. No overwriting should be done.
Time: 20 Minutes
(20 x 1 = 20 Marks)

• 1.Components of the complement cascade are:
  a) Glycolipids
  b) Antibodies
  c) Precursors of enzymes
  d) Hormones

• 2.Which is not a method of gene therapy?
  a) FISH
  b) Transfection
  c) Electroporation
  d) Bacteriophage

• 3.Resistance developed in an individual as a result of antigenic stimulus is:
  a) Natural immunity
  b) Artificial immunity
  c) Passive acquired immunity
  d) Active acquired immunity

• 4.Bence Jones proteins excreted in urine in Multiple Myeloma are composed of:
  a) Intact Immunoglobulins
  b) Albumin
  c) Heavy chains of Immunoglobulins
  d) Light chain of Immunoglobulins

• 5.Amino acids secreted in Cystinuria are all, except:
  a) Ornithine
  b) Histidine
  c) Arginine
  d) Lysine

• 6.Garrod’s tetrad includes all of the following, except:
  a) Alkaptonuria
  b) Cystinuria
  c) Pentosuria
  d) Phenylketonuria

• 7.HLA genes are located on:
  a) Long arm of Chr 7
  b) Short arm of Chr 6
  c) Long arm of Chr 8
  d) Short arm of Chr 7

• 8.End product of purine metabolism in non-primates:
  a) Uric acid
  b) Allantoin
  c) Beta alanine
  d) Ammonia

• 9.Glycine contributes to the following atoms of purine ring:
  a) C4, C5 and N7
  b) C2, C6 and N1
  c) C4, C6 and N1
  d) C2, C5 and N7

• 10.Lighter staining heterochromatic region of DNA that is relatively transcriptionally active is:
  a) Non-condensed
  b) Condensed
  c) De-condensed
  d) Partially condensed

• 11.Which type of rRNA has the highest percentage of modified bases?
  a) mRNA
  b) tRNA
  c) rRNA
  d) snRNA

• 12.Collagen does not undergo the following post-translational modification:
  a) Hydroxylation
  b) Glycosylation
  c) Cross linking
  d) Gamma-carboxylation

• 13.All the minerals function as antioxidants, except:
  a) Manganese
  b) Zinc
  c) Selenium
  d) Copper

• 14.A compound that links citric acid cycle and urea cycle is:
  a) Malate
  b) Citrate
  c) Succinate
  d) Fumarate

• 15.Which of the following diseases manifest ketosis?
  a) Phenylketonuria
  b) MSUD
  c) Tyrosinemia
  d) Alkaptonuria

• 16.Enzyme responsible for respiratory burst is:
  a) NADPH-oxidase
  b) Nitric oxide synthase
  c) Glutathione peroxidase
  d) Catalase

• 17.A deficiency of copper affects the formation of normal collagen by reducing the activity of:
  a) Prolyl hydroxylase
  b) Lysyl oxidase
  c) Lysyl hydroxylase
  d) Glucose transferase

• 18.The urine sample of a patient with Maple Syrup Urine Disease will be positive for:
  a) Biuret test
  b) Ferric chloride test
  c) Dinitrophenylhydrazine test
  d) Cyanide nitroprusside test

• 19.Transplacental transfer of maternal IgG antibodies induces:
  a) Active immunity
  b) Active artificial immunity
  c) Passive natural immunity
  d) Passive artificial immunity

• 20.Which of the following is a semi-essential amino acid?
  a) Valine
  b) Methionine
  c) Arginine
  d) Leucine

ATAL BIHARI VAJPAYEE MEDICAL UNIVERSITY
MBBS DEGREE EXAMINATION – 1ST PROFESSIONAL-SUPPLEMENTARY EXAM – DEC 2024
BIOCHEMISTRY – PAPER II
Max. Marks: 100 Marks (80 Theory + 20 MCQs)
TIME: 3 Hrs

NOTE:

• Attempt all questions.

• This question paper consists of two sections: Section A - Multiple Choice Questions and Section B - Theory Questions.

• Both sections have different paper codes. Write correct paper code on the respective sheet.

• Write correct MCQ paper set on the OMR sheet.

• Answer MCQs on the provided OMR sheet and theory questions on the provided answer booklet.

SECTION B – THEORY QUESTIONS

PAPER CODE: 2422230003

Q.1 Long Answer Question – 15 MARKS

i) Elaborate the steps of Heme synthesis. (4 marks)
ii) Discuss the enzyme defects and associated disorders. (6 marks)
iii) Discuss clinical features and treatment options of the above disorders. (5 marks)

Q.2 Clinical Case Scenario based Structured Question – 15 MARKS

A 7-day-old boy presented with poor feeding and convulsions since birth. On examination, the smell of burnt sugar was there from the body. His plasma and urine show increased levels of alpha-keto acids and alpha-hydroxy acids.
i) What is the diagnosis? Justify. (3 marks)
ii) Explain the biochemical basis of the disorder. (2 marks)
iii) What are the characteristic clinical features of the disorder? (5 marks)
iv) Write down the name of at least 3 disorders which can be diagnosed from the characteristic smell of urine. (5 marks)

Q.3 Short Note Question (Within 500 Words) – 5 x 6 = 30 MARKS

i) Discuss the metabolic importance of transamination reactions. Also, discuss the clinical importance of transaminase estimation.
ii) Discuss tumor markers.
iii) Explain the process of protein digestion and absorption in the body.
iv) Briefly outline the salvage pathway for purine synthesis. Also, discuss the biochemical basis of severe combined immunodeficiency disorder (SCID).
v) Discuss the role of a physician in the healthcare system. Also, discuss the significance of lifelong learning for a physician.

Q.4 Short Answer Questions (Within 100 Words) – 5 x 4 = 20 MARKS

i) Explain with the help of a diagram: Why does the Okazaki fragment lag behind the leading strand in DNA replication?
ii) Discuss briefly about the genetic code.
iii) Discuss special products and fate of Glycine.
iv) Discuss osteogenesis imperfecta.
v) Discuss the secondary structure of protein.

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