Biochemistry Paper-2 (Supplementary), 2022 MBBS Batch ABVMU Lucknow

ATAL BIHARI VAJPAYEE MEDICAL UNIVERSITY, LUCKNOW

MBBS DEGREE EXAMINATION - Ist PROFESSIONAL-SUPPLEMENTARY EXAM - MARCH-2024

BIOCHEMISTRY - PAPER - II

SECTION A - Multiple Choice Questions (MCQs)

PAPER CODE: 2422130003 SET: C

Note: Choose one correct answer in the OMR sheet provided. No overwriting should be done.

Time: 20 Minutes (20 x 1 = 20 MARKS)

1. The substance that facilitates protein degradation is:

a) phylloquinone b) ubiquinone c) ubiquitin d) menaquinone

2. Enzymes responsible for respiratory burst

a) Dehydrogenases b) Peroxidases c) NADPH oxidase d) Hydroxylases

3. The primary defect in Xeroderma pigmentosa is:

a) Poly ADP ribose polymerase is defective b) Formation of thymidine dimers c) Formation of adenine dimers d) Exonuclease is defective

4. Starting material for production of insulin from bacteria is

a) Genomic DNA of lymphocytes b) mRNA of beta cells of pancreas c) mRNA of lymphocytes d) Genomic DNA of beta cells of pancreas

5. Nitric acid is a signaling molecule produced from

a) cysteine b) methionine c) arginine d) glutamine

6. Amino acids which absorb ultra violet light are

a) Basic amino acids b) Aromatic amino acids c) Acidic amino acids d) Neutral amino acids

7. Which of the following is an antiapoptotic gene

a) P53 b) C-myc c) Bax d) Bcl-2

8. Antigen binding site on immunoglobin is

a) Variable region b) Constant region c) Hyper variable region d) Hinge region

9. Vitamin required for post-translational modification of coagulants is

a) Vitamin A b) Vitamin B6 c) Vitamin K d) Vitamin E

10. The amyloid protein deposition associated with Alzheimer's disease is composed of

a) Beta pleated sheet b) Alpha helix c) Tertiary structure d) Quaternary structure

11. One of the nitrogen atom of urea molecule is provided by

a) Aspartate b) Citrulline c) Ornithine d) Glutamate

12. Thermo-stability in DNA is contributed mostly by

a) G-C b) A-T c) Parallel arrangement d) Molecular base

13. Glutathione is a tri-peptide made up of

a) Glutamate + methionine + arginine b) Glutamate + glycine + arginine c) Glutamate + alanine + arginine d) Glutamate + cysteine + glycine

14. Rate limiting step for the entire process of hepatic bilirubin metabolism is

a) Uptake of bilirubin by liver b) Transport of bilirubin with albumin c) Secretion of conjugated bilirubin into the bile d) Conjugation of bilirubin

15. Glutamine in blood acts as:

a) Toxic element b) NH3 transporter c) Abnormal metabolite d) Stored energy

16. An Amino Acid which becomes essential in phenylketonuria is

a) Tyrosine b) Phenylalanine c) Methionine d) Tryptophan

17. Which of the following test is used to detect proteinuria

a) Fouchet test b) Heat coagulation and acetic acid test c) Benzidine test d) Hay's sulphur test

18. Antibody that can cross placenta to protect fetus

a) IgG b) IgA c) IgE d) IgM

19. The enzyme deficient in Lesch-Nyhan syndrome is

a) HGPRTase b) Glutaminase c) Transcarboxylase d) GTRT

20. The mutation found in sickle cell anaemia can be classified as

a) Non-sense mutation b) Silent mutation c) Insertion d) Mis-sense mutation

ATAL BIHARI VAJPAYEE MEDICAL UNIVERSITY, LUCKNOW

MBBS DEGREE EXAMINATION - I st PROFESSIONAL-SUPPLEMENTARY EXAM - MARCH-2024

BIOCHEMISTRY - PAPER - II

TIME: 3 Hrs Max. Marks: 100 Marks (80 Theory + 20MCQs)

NOTE:

Attempt all questions.

This question paper consists of two sections: Section A- Multiple Choice Questions and Section B- Theory Questions.

Both the section has different paper code. Write correct paper code on respective sheet

Write correct MCQ paper set on OMR sheet

Answer MCQs on the provided OMR sheet and theory questions on the provided answer booklet.

SECTION B - THEORY QUESTIONS

PAPER CODE : 2422230003

Q.1 Long Answer Questions 15 MARKS

i) Enumerate and discuss the 4 stages which occur in conversion of α-amino group to urea 3 marks

ii) Describe Urea cycle with the help of schematic diagram. 4 marks

iii) What is the normal range of Urea in blood? 1 marks

iv) Discuss the disorders associated with Urea cycle. 5 marks

v) Which is a better marker of Kidney function urea or creatinine and why? 2 marks

Q.2 Clinical Case Scenario based Structured Question (15 MARKS)

A 52 year old male presents to the emergency department of hospital with excruciating pain in the left great toe. There was no history of injury however he gave history of binge drinking the previous night. Medical history revealed that he is a chronic alcoholic with history of renal stones.

On examination, he had mild fever (100.8°F) and his left toe was warm, swollen and tender to touch.

Lab investigation revealed: Serum Uric Acid 10.9 mg/dL (Normal 2-7 mg/dL), Urine Uric acid 480 mg/day (Normal 250-700 mg/day)

i) What is the likely diagnosis? 1 marks

ii) What is the cause of pain and swelling of joint? 2 marks

iii) Which drug may benefit this patient? Describe in detail along with its mechanism of action 5 marks

iv) Enumerate the primary and secondary causes that may lead to this disease. 2 marks

v) Describe briefly the salvage pathway of Purines. 5 marks

Q.3 Short Note Question (Approx 500 Words) 5 X 6 = 30 MARKS

i) Discuss metabolism of Tyrosine. Why is Tyrosine considered as semi-essential amino acid. Name various inborn errors of metabolism associated with its pathway. Discuss any one in detail.

ii) Enumerate and describe the role of a physician in health care system.

iii) Describe the structure and function of various immunoglobulin.

iv) What is PCR? Describe the steps of PCR. Enumerate diagnostic uses of PCR.

v) Classify Porphyrias with the enzyme defect. Mention signs and symptoms of acute intermittent porphyria.

Q.4 Short Answer Questions (Within 100 Words) 5 X 4 = 20 MARKS

i) Discuss Hartnup disease.

ii) Discuss post-translational modifications.

iii) Discuss any collagen associated disorder.

iv) Define tumor markers and enlist six clinically important tumor markers with associated cancer.

v) Discuss protein targeting and sorting. Discuss any one associated disorder.

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