Biochemistry Paper-2 (Supplementary), 2020 MBBS Batch ABVMU Lucknow

MBBS: Biochemistry Paper 2 Part 1. ABVMUUP Paper Code: 2122130003

Q1. Give a detailed account of the transcription process. (20 marks)

How is it regulated? Name inhibitors of transcription.

Q2. Write briefly on: (4 x 5 = 20 marks)

(a) Multiple myeloma

(b) GTT

(c) Mutations

(d) Genetic code

Q3. Multiple Choice Questions: (Each question carries 1 mark = 10)

a. Gene amplification can be achieved by:

A) Southern blotting

B) DNA finger printing

C) Polymerase chain reaction

D) Gene cloning

b. All the following are nucleic acids, EXCEPT:

A) Plasmids

B) Prions

C) Cosmids

D) Virons

c. Negative nitrogen balance is observed in:

A) Pregnancy

B) Chronic fever

C) Convalescence

D) Growth period

d. Which enzymes protects DNA from ageing?

A) DNA polymerase

B) Topoisomerase

C) Deoxyribonuclease

D) Telomerase

e. Serum alkaline phosphatase is increased in:

A) Hypothyroidism

B) Carcinoma of prostate

C) Bone diseases

D) Myocardial infarction

f. Proximal renal tubular acidosis is characterized by all, EXCEPT

A) Metabolic acidosis

B) Normal anion gap

C) Urine pH of 4.5

D) Hyperchloremia

g. Which is the anticoagulant of choice for biochemical estimation in general:

A) EDTA

B) Oxalate-fluoride mixture

C) Lithium heparin

D) Citrate

h. Which anions are present in normal urine:

A) Phosphate

B) Sulfate

C) Chloride

D) Proteinate

i. A patient with infective hepatitis is likely to have all the following findings, except:

A) Hyperbilirubinemia

B) Bilirubinuria

C) Absence of bile salts in urine

D) Elevated AST

j. All the techniques listed below measures proteins, except:

A) Nephelometry

B) Flame photometry

C) ELISA

D) Radial immunodiffusion

MBBS: Biochemistry Paper 2 Part 2. ABVMUUP Paper Code: 2122230003

Q1. What are xenobiotics? Describe the role of glutathione in detoxification. (20 marks)

Q2. Write short notes on: (5 marks each = 20)

a. Maple syrup urine disease

b. Gonadotropins

c. Oncogenes

d. Visual cycle

Q3. Multiple choice questions: (Each question carries 1 mark: Total 10 marks)

a. In the human body, the highest concentration of ascorbic acid is found in:

A) Liver

B) Adrenal cortex

C) Posterior pituitary gland

D) Muscle

b. The metal present in vitamin B12 is:

A) Copper

B) Cobalt

C) Chromium

D) Manganese

c. Alpha-fetoprotein level in serum is increased in:

A) Prostatic cancer

B) Hepatoma

C) Lung cancer

D) Nephritis

d. Name the defective enzyme in phenylketonuria:

A) Cystathionase

B) Phenylalanine hydroxylase

C) Homogentisic acid oxidase

D) Para-hydroxyphenylpyruvate oxidase

e. Nutritional status of a person can be assessed by all, EXCEPT:

A) Serum protein estimation

B) Hemoglobin level

C) Gain or loss in weight

D) Mid-arm circumference

f. Features of galactosemia include the following, EXCEPT:

A) Cataract

B) Hepatosplenomegaly

C) Mental retardation

D) Hemolytic anemia

g. Sunlight helps maximally in the synthesis of which of the following vitamins in the body:

A) Vitamin A

B) Vitamin B

C) Vitamin C

D) Vitamin D

h. All the following are characteristics of thalassemia major, EXCEPT:

A) It is manifested when the affected genes are in a homozygous state

B) It is the result of gene deletion

C) It is a common molecular disease in India

D) It is incompatible with life

i. Nyctalopia (abnormal inability to see in dim light) is due to the deficiency of:

A) Vitamin K

B) Vitamin E

C) Vitamin B12

D) Vitamin A

j. Steroid hormones are produced from:

A) Purine

B) Pyrimidine

C) Cholesterol

D) Stercobilinogen

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