Biochemistry Paper-2 (Main), 2023 MBBS Batch ABVMU Lucknow

ATAL BIHARI VAJPAYEE MEDICAL UNIVERSITY, LUCKNOW

MBBS DEGREE EXAMINATION - Ist PROFESSIONAL - REGULAR EXAM - AUGUST-2024

BIOCHEMISTRY - PAPER - II

SECTION A - Multiple Choice Questions (MCQs)

PAPER CODE: 2412130003 SET: C

Note: Choose one correct answer in the OMR sheet provided. No overwriting should be done.

(20 x 1 = 20 MARKS) Time: 20 Minutes

1 A patient with increased Hypoxanthine and Xanthine in blood with hypouricemia, which enzyme is deficient?

a) Xanthine oxidase b) APRTase c) Adenosine deaminase d) HGPRTase

2 Which of the following is the characteristic feature of Oroticaciduria?

a) Pernicious anaemia b) Sideroblastic anaemia c) Megaloblastic anaemia d) Iron deficiency and

3 Major type of collagen in basement membrane:

a) Type II b) Type IV c) Type III d) Type I

4 Hyperuricemia is not found in:

a) Psoriasis b) Von Gierke's disease c) Cancer d)

5 All of the following are examples of housekeeping genes except

a) Beta galactosidase b) RNA polymerase c) rRNA genes d) Ribosomal protein genes

6 All of the techniques listed below measure protein except

a) Electrophoresis b) ELISA c) Flame photometry d) Nephelometry

7 Which of the following enzymes is described as a RNA dependent DNA polymerase?

a) Primase b) Reverse Transcriptase c) DNA polymerase III d) DNA ligase

8 Which one of the following enzyme of heme synthesis is dependent ton pyridoxal phosphate (PLP)?

a) Ferrochelatane b) Protoporphyrinogen oxidase c) ALA Synthase d) PBG Synthase

9 Which of the following is not an acute phase protein?

a) Ceruloplasmin b) C-reactive protein c) Transcortin d) Alpha-1 anti-trypsin

10 Benco Jones protein precipitates at

a) 60° C b) 20°-40° C c) 60°-80° C d)

11 Imidazole ring is present in

a) Tryptophan b) Proline c) Histidine d) Arginine

12 Thamplacental transfer of maternal IgG antibodies induces

a) Artificial immunity b) Passive artificial immunity c) Passive natural immunity d) Active natural inmmunity

13 All the following enzymes of heme synthesis are located in mitochondria except:

a) Hydoxymethylbilane Synthase b) Protoporphyrinogen oxidase c) Ferrochelatase d) ALA Synthase

14 A 4 week old infant was passing urine which smelled like burnt sugar. Concentration of branched chain amino acids in urine and plasma were found to be very high. is the probable cause?

a) Alkaptonuria b) Cystinuria c) Maple syrup urine disease d) Phenylketonuria

15 Presence of carcinoembryonic antigen (CEA) in serum is detected in:

a) Germ cell tumour of testis b) Choriocarcinoma c) Colorectal cancer d) Hepatoma

16 Substitution of which of the following amino acids in place of alanine would increase the absorbance of proteins at 280nm

a) Arginine b) Protein c) Tryptophan d) Leucine

17 A professional body builder on high protein diet went for routine health check-up. Which of these parameters is expected to be high in blood sample in his case?

a) Serum uric b) Serum bilirubin c) Serum urea d) Serum creatinine

18 An infant came to OPD with complains of dark urine stained diaper which on exposure becomes darker Probable diagnosis

a) Phenylalan hydroxylase b) Hepatic transaminase c) Fumaryl acetoacetate hydrolase deficiency d) Homogentisate oxidase deficiency

19 What is mechanism of Allopurinol in lowering serum uric acid levels?

a) Non competitive inhibition b) Feedback inhibition c) Allosteric inhibition d) Suicidal inhibition

20 A car old presented to eye OPD with complaint of diminished vision in both eyes. Physical examination showed arachnodactyly, dislocation of lens and hyperextension of joints. Identify the disease and defective protein associated with

a) Marfan's syndrome - Fibrillin 1 protein b) Menke's syndrome - Lysyl oxidase c) Osteogenesis Imperfecta - Collagen typel d) Ehler - Danlos syndrome - Lysyl oxidase

ATAL BIHARI VAJPAYEE MEDICAL UNIVERSITY, LUCKNOW

MBBS DEGREE EXAMINATION - Ist PROFESSIONAL - REGULAR EXAM - AUGUST-2024

BIOCHEMISTRY - PAPER - II Max. Marks: 100 Marks (80 Theory + 20MCQs) TIME: 3 Hrs

NOTE:

Attempt all questions.

This question paper consists of two sections: Section A- Multiple Choice Questions and Section B- Theory Questions

Both the section has different paper code. Write correct paper code on respective sheet

Write correct MCQ paper set on OMR sheet

Answer MCQs on the provided OMR sheet and theory questions on the provided answer booklet.

SECTION B - THEORY QUESTIONS

PAPER CODE: 2412230003

Q.1 Long Answer Question. ( 15 MARKS )

i) Discuss Eukaryotic Translation process with the help of illustrated diagram 7 marks

ii) Discuss post-translational modifications and inhibitors of translation. 5 marks

iii) Give differences between eukaryotic and prokaryotic translation. 3 marks

Q.2 Clinical Case Scenario based Structured Question (15 MARKS)

A 18 months old male child was admitted to NICU with history of continuous vomiting since three days, poor feeding, and deterioration of consciousness. He was born after a full-term uneventful gestation, by caesarean section. Birth weight was 3600 grams. His older sibling died of similar illness at the age of two years. His serum ammonia levels were found to be very high. On tandem mass spectrometry, his citrulline levels were very low. He deteriorated rapidly afterward and died three days later.

i) Which enzyme defect would you suspect in this child & discuss its inheritance pattern. 2 marks

ii) Discuss the metabolic pathway which is defective in above mentioned illness? 5 marks

iii) Why ammonia is neurotoxic? 2 mark

iv) How is ammonia normally transported and detoxified. 2 mark

v) List 4 causes of hyperammonemia 4 mark

Q.3 Short Note Question (Approx 500 Words) 5 X 6 = 30 MARKS

i) Enumerate the functions and components of extracellular matrix.

ii) Discuss causes, clinical features and treatment of Gout.

Discuss Thalassemia: Definition, types and causes.

iv) Discuss Classical complement pathway.

v) Discuss the role of a physician in health care system. Also discuss significance of lifelong learning for physician

Q.4 Short Answer Questions (Within 100 Words) 5 X 4 = 20 MARKS

i) Discuss hemolysis in G6PD deficiency.

ii) Discuss Multiple myeloma

Compare characteristic features of tumor cells with normal cells.

iv) Discuss tumor markers.

v) Discuss the metabolism of Phenylalanine. Name the various inborn errors of metabolism associated with it.

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