Biochemistry Paper-1 (Supplementary), 2022 MBBS Batch ABVMU Lucknow

ATAL BIHARI VAJPAYEE MEDICAL UNIVERSITY, LUCKNOW

MBBS DEGREE EXAMINATION - Ist PROFESSIONAL-SUPPLEMENTARY EXAM - MARCH-2024

BIOCHEMISTRY-PAPER-I

SECTION A - Multiple Choice Questions (MCQs) SET: B

PAPER CODE: 2421130003

Note: Choose one correct answer in the OMR sheet provided. No overwriting should be done.

(20 x 1 = 20 MARKS) Time: 20 Minutes

1 In mammals, the major fat in adipose tissues is

a) Cholesterol b) Phospholipid c) Triacylglycerol d) Sphingolipids

2 G-proteins act as

a) Hormone receptors b) Hormone carriers c) Signal transducers d) Second messengers

3 Vitamin required in conversion of folic acid to folinic acid is

a) Cobalamin b) Biotin c) Niacin d) Ascorbic acid

4 Enterokinase is involved in activation of

a) Pepsinogen b) Trypsinogen c) Chymotrypsinogen d) Pro-elastase

5 Dietary fats after absorption appear in the circulation as

a) VLDL b) Chylomicron c) HDL d) LDL

6 Which of the following is a substrate for aldolase activity in Glycolytic pathway?

a) Glucose-6-p b) Glyceraldehyde-3-p c) Fructose1,6-bisphosphate d) Fructose-6-p

7 Depression of respiratory centre by use of overdose of anaesthetics may cause

a) Respiratory alkalosis b) Respiratory acidosis c) Metabolic alkalosis d) Metabolic acidosis

8 Which organ cannot utilize fatty acids

a) Adipose tissue b) Brain c) Skeletal muscles d) Liver

9 Triglycerides are

a) Major constituents of membranes b) Heavier than water c) Hydrophilic d) Non-polar

10 The sites for gluconeogenesis are

a) Skin and pancreas b) Liver and kidney c) Intestine and lens of eye d) Lung and brain

11 Carpal tunnel syndrome may occur if there is deficiency of

a) Folic acid b) B12 c) Niacin d) B6

12 The vitamin which would most likely become deficient in an individual who develop a completely carnivorous life style

a) Niacin b) Thiamin c) Cobalamin d) Vitamin C

13 Glycogen is present in all body tissues except

a) Brain b) Liver c) Stomach d) Kidney

14 Which one of the following compounds cannot give rise to the net synthesis of Glucose?

a) α-ketoglutarate b) Lactate c) Acetyl CoA d) Glycerol

15 Substrate for synthesis of Eicosanoids is

a) Oleic acid b) Arachidonic acid c) Palmitic acid d) Linolenic acid

16 Example of an extracellular enzyme is

a) Cytochrome oxidase b) Lactate dehydrogenase c) Hexokinase d) Pancreatic lipase

17 Which of the following enzyme is not involved in HMP shunt?

a) Glucose-6-p-dehydrogenase b) Glyceraldehyde-3-p dehydrogenase c) Phosphogluconate dehydrogenase d) Transketolase

18 Poor source of iron is

a) Meat b) Milk c) Kidney d) Liver

19 Dietary deficiency of thiamin inhibits the activity of the enzyme:

a) Pyruvate dehydrogenase b) Pyruvate kinase c) Enolase d) Phosphofructokinase

20 Insulin stimulates

a) Hepatic glycogenesis b) Hepatic glycogenolysis c) Gluconeogenesis d) Lipolysis

ATAL BIHARI VAJPAYEE MEDICAL UNIVERSITY, LUCKNOW

MBBS DEGREE EXAMINATION - I st PROFESSIONAL-SUPPLEMENTARY EXAM - MARCH-2024

BIOCHEMISTRY - PAPER - I

TIME: 3 Hrs Max. Marks: 100 Marks (80 Theory + 20MCQs)

NOTE:

Attempt all questions.

This question paper consists of two sections: Section A- Multiple Choice Questions and Section B- Theory Questions.

Both the section has different paper code. Write correct paper code on respective sheet

Write correct MCQ paper set on OMR sheet

Answer MCQs on the provided OMR sheet and theory questions on the provided answer booklet.

SECTION B - THEORY QUESTIONS

PAPER CODE : 2421230003

Q.1 Long Answer Questions 15 MARKS

i) Enumerate Ketone bodies found in our blood. 1 mark

ii) Explain Ketogenesis and Ketolysis with the help of schematic diagram. 5 marks

iii) Define Ketosis. Discuss the biochemical basis for occurrence of Ketosis as a complication of Diabetes mellitus and starvation. 5 marks

iv) Discuss the complications associated with ketosis. 1 mark

v) Enumerate the test performed to detect Ketone bodies in urine. 1 mark

vi) Explain why hepatocytes could synthesize Ketone bodies but could not utilize them. 2 marks

Q.2 Clinical Case Scenario based Structured Question (15 MARKS)

A 50 year old male presented to medicine OPD with complaints of weakness and increased frequency of thirst, hunger and urination. On physical examination his BMI was 33.2 kg/m2. Oral Glucose tolerance test (OGTT) revealed following values: Fasting blood glucose: 128mg/dl; 1 hour glucose: 186mg/dl; 2 hours glucose: 220mg/dl, Urine sample gave brick red colour on Benedict's test.

i) Interpret the oral GTT report with proper reasoning 2 marks

ii) Interpret Urine Benedict test and why is it called semi-quantitative test. 2 marks

iii) What is normal glucose concentration in urine? 1 mark

iv) Explain the biochemical basis for symptoms. 3 marks

v) Explain the role of hormones in regulation of blood glucose. 5 marks

vi) Mention what other tests we could perform to confirm our diagnosis. 2 marks

Q.3 Short Note Question (Approx 500 Words) 5 X 6 = 30 MARKS

i) Schematic representation of Electron transport chain

ii) Cytochrome P-450 and its role in Xenobiotics

iii) Discuss biochemical significance and disease states associated with copper.

iv) Define Isoenzymes & discuss their role in diagnosis of Myocardial infarction.

v) Discuss the risks associated with obesity.

Q.4 Short Answer Questions (Within 100 Words) 5 X 4 = 20 MARKS

i) Differentiate between primary and secondary active transport with suitable examples.

ii) Compare and contrast competitive and noncompetitive enzyme inhibition.

iii) Compare and contrast Marasmus and Kwashiorkor.

iv) Discuss inhibitors of Eicosanoid synthesis.

v) Differentiate between pre-hepatic and hepatic jaundice.

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